dor_id: 1501403

506.#.#.a: Público

650.#.4.x: Biología y Química

336.#.#.b: other

336.#.#.3: Registro de colección de proyectos

336.#.#.a: Registro de colección universitaria

351.#.#.b: Proyectos Universitarios PAPIIT (PAPIIT)

351.#.#.a: Colecciones Universitarias Digitales

harvesting_group: ColeccionesUniversitarias

270.1.#.p: Dirección General de Repositorios Universitarios. contacto@dgru.unam.mx

590.#.#.c: Otro

270.#.#.d: MX

270.1.#.d: México

590.#.#.b: Concentrador

883.#.#.u: https://datosabiertos.unam.mx/

883.#.#.a: Portal de Datos Abiertos UNAM, Colecciones Universitarias

590.#.#.a: Administración central

883.#.#.1: http://www.ccud.unam.mx/

883.#.#.q: Dirección General de Repositorios Universitarios

850.#.#.a: Universidad Nacional Autónoma de México

856.4.0.u: http://datosabiertos.unam.mx/DGAPA:PAPIIT:IN219709

100.1.#.a: Dimitrios Georgellis

524.#.#.a: Dirección de Desarrollo Académico, Dirección General de Asuntos del Personal Académico (DGAPA). "Characterization of the BarA/UvrY two component signal transduction system of Escherichia coli", Proyectos Universitarios PAPIIT (PAPIIT). En "Portal de datos abiertos UNAM" (en línea), México, Universidad Nacional Autónoma de México.

720.#.#.a: Dimitrios Georgellis

245.1.0.a: Characterization of the BarA/UvrY two component signal transduction system of Escherichia coli

502.#.#.c: Universidad Nacional Autónoma de México

561.1.#.a: Instituto de Fisiología Celular, UNAM

264.#.0.c: 2009

264.#.1.c: 2009

307.#.#.a: 2019-05-23 18:40:21.491

653.#.#.a: Transducción de señales; Biología molecular y genética

506.1.#.a: La titularidad de los derechos patrimoniales de este recurso digital pertenece a la Universidad Nacional Autónoma de México. Su uso se rige por una licencia Creative Commons BY 4.0 Internacional, https://creativecommons.org/licenses/by/4.0/legalcode.es, fecha de asignación de la licencia 2009, para un uso diferente consultar al responsable jurídico del repositorio por medio de contacto@dgru.unam.mx

041.#.7.h: spa

500.#.#.a: The BarA-UvrY two-component signal transduction system has been described in several animal and plant pathogens, such as Escherichia, Pseudomonas, Vibrio, Erwinia, Legionella, and Salmonella genera, and has been associated with phenotypes such as motility, biofilm formation and pathogenic interactions. The target genes are not well defined, although there is a strong connection to virulence functions as the expression of numerous virulence genes, specific to each pathogen, are controlled by this system. We propose to probe for the physiological signals that stimulate the BarA sensor kinase, to elucidate the routes of phosphoryl-group transfer for signal transmission and signal decay, to search for the member genes of the UvrY regulon, to identify the conserved functions of the various UvrY orthologs, and to screen libraries of small molecules with the intention of identifying antimicrobial agents that specifically target these systems. To address these questions we will primarily use E. coli as the model organism, and a wide array of biochemical and genetic techniques. Accomplishment of the goals should not only clarify the mechanisms of BarA-UvrY signal transduction and its scope of control, but could also improve our understanding of the integration of genetic circuits for bacterial adaptation to environmental changes, including those associated with host invasion during pathogenesis.

046.#.#.j: 2019-11-14 12:26:40.706

264.#.1.b: Dirección General de Asuntos del Personal Académico

handle: 00e8e0d0992ba9a9

harvesting_date: 2019-11-14 12:26:40.706

856.#.0.q: text/html

last_modified: 2019-11-22 00:00:00

license_url: https://creativecommons.org/licenses/by/4.0/legalcode.es

license_type: by

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